Seminars & Speakers


Warning: preg_replace(): The /e modifier is no longer supported, use preg_replace_callback instead in /home/seminars/www/g4s/bbs/view.php on line 125
Tuberculosis disease propagation and implications for drug discovery
Speaker Vincent Delorme
Affiliation Insitut Pateur Korea
URL Link
Date May 9, 2019
Time 4:00 pm
Venue Bldg.110 Rm. N104
Sponsor UNIST-Life Sciences
Host Hyung Moo Kwon
Contact hmkwon@unist.ac.kr
Phone 2535
Attach 콜로퀴움 포스터.jpg (2.2M)
Mycobacterium tuberculosis (Mtb) is the major etiologic agent for tuberculosis inhuman. This terrible disease was responsible for 1.6 million deaths globally in 2017, and10 million new people were estimated to have been newly infected in the same year. Mtbis an obligate human pathogen, able to efficiently infect the lungs and establish long-term, asymptomatic infections hidden from the immune system, before eventuallytriggering a burst phase of extensive caseous pneumonia and cavitation for transmission to new hosts. Here, we will review the cascade of events leading to the active disease,based on available histopathological evidence, and explain the concepts and misconceptions about latent tuberculosis infection (LTBI).
These considerations will help us understand why the clinical treatment of tuberculosis isso difficult and lengthy, despite the use of extremely potent antibiotics. We will alsohighlight the necessity for developing well-understood drug combination regimens, and emphasize how drug-resistant Mtb can be a major threat to the successful controlof the global tuberculosis epidemic. Finally, we will summarize some of the work doneand on-going at Institut Pasteur Korea to try to tackle the gaps in drug discovery and development.
 
 
Keywords: Mycobacterium tuberculosis (Mtb), latent & active tuberculosis, drug-resistance, drug development
​