Seminars & Speakers


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Structural reorganization and leaflet coupling driven by curvature in model membranes
Speaker Sin-Doo Lee
Affiliation Seoul National University
URL Link
Date December 3, 2018
Time 4:00 pm
Venue UNIST Bldg. 103, Rm 309
Sponsor IBS-Center for Soft and Living Matter
Host Joonwoo Jung
Contact jeewonchoi.e@gmail.com
Phone 5527
Attach New_Seminar_announcement_Lee.pdf_page_1.jpg (575.7K)
 Cellular membranes exhibit lateral heterogeneity through the compartmentalization of lipids, proteins, and carbohydrate molecules. Cholesterol and sphingolipid-rich membrane microdomains, termed lipid rafts, have attracted much attention for their critical roles in cellular processes through the structural organization and the regulation of protein activation, signaling, and pathogenesis/treatment of neurological and psychiatric disorders. In a dynamically fluctuating cellular membrane, membrane deformations by curvatures can effectively remodel the spatial distribution of lipids, including raft molecules, depending on the geometrical shapes of lipids and vice versa. Of particular significance is to explore how the curvature influences the asymmetric distribution of lipids across the membrane
leaflets in the process of domain growth. We observed that in an alternatively curved supported lipid bilayer membrane, the raft domains are initiated only in the leaflet with negative curvature and promoted into the opposing leaflet with positive curvature through the inter-leaflet coupling between bilayers as confirmed in specific binding of antibodies to glycolipid receptors. Our asymmetric leaflet approach serves as a robust platform for the investigation of other putative raft-binding molecules. 
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